Eventually, this maxes out, and it goes and adds the receptor system for which it has the second greatest affinity. By about 20mg, you've gotten as much serotonin effect as you are going to ever get. Do you expect the clinical difference from 10mg to 20mg to be snificant? The old ones-- Thorazine, Elavil, Pamelor, Remeron, Wellbutrin-- all blunt instruments, single receptor system drugs? From the Celexa package insert: (warning: PDF-- clear your schedule) 2. This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. If everyone reading this would donate then this fund raiser would be done in an hour. A drug with affinity for multiple receptors doesn't bind to all of them simultaneously, but rather sequentially, like an aging polygamist, starting with the system for which it has the greatest affinity. That first S stands for selective (serotonin reuptake inhibitor.) Allof it's clinical effect is coming from one single receptor system; this rum fountain has only one level-- and it's not that deep. No, because they are both doing the same thing: blocking about 80% of serotonin transporters. From An Inconvenient Truth, 2006 This is why Effexor studies only show superior efficacy at doses above 150mg-- because at 150mg, you start adding N on top of your already maxed out S.
Is higher dose of effexor better
Effexor is a dual purpose antidepressant released by Wyeth-Ayerst Laboratories and approved by the FDA in October 1997. I can't sleep when I go to bed, and when I finally fall asleep at 6am I can't get out of bed. I've found it to be quite a good drug, except, I have been unable to come off of it without relapsing. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients User Ratings / Reviews Side Effect Reports Below are Effexor XR (Venlafaxine) reviews, ratings, comments submitted by patients and caregivers.
Immediate release 25-50 mg/day PO divided q8-12hr initially; may be increased as tolerated by ≤25 mg/day no faster than every 4 days Moderate: Up to 225 mg/day PO divided q8-12hr Severe: Up to 375 mg/day PO divided q8-12hr Extended release 37.5 mg PO once daily initially; may be increased by 37.5 mg/day every 4-7 days; not to exceed 225 mg/day Headache (25-38%) Nausea (21-58%) Insomnia (15-24%) Asthenia (16-20%) Dizziness (11-24%) Ejaculation disorder (2-19%) Somnolence (12-26%) Dry mouth (12-22%) Diaphoresis (7-19%) Anorexia (15-17%) Nervousness (17-26%) Anorgasmia (5-13%) Weht loss (1-6%) Abnormal vision (4-6%) Hypertension (2-5%) Impotence (4-6%) Paresthesia (2-3%) Tremor (1-10%) Vasodilation (2-6%) Vomiting (3-8%) Weht gain (2%) Flatulence (3-4%) Pruritus (1%) Yawning (3-8%) Dyspepsia (5-7%) Twitching (1-3%) Mydriasis (2%) 65 years Not FDA approved for children; in children and young adults; benefits of taking antidepressants must be wehed against risks Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial 1-2 months of therapy and dosage adjustments Patient’s family should communicate any abrupt behavioral changes to healthcare provider Worsening behavior and suicidal tendencies that are not part of presenting symptoms may necessitate discontinuance of therapy Not FDA approved for treatment of bipolar depression Risk of mydriasis; may trger angle closure attack in patients with angle closure glaucoma with anatomiy narrow angles without a patent iridectomy Use caution in bipolar mania, history of seizures, and cardiovascular disease May precipitate mania or hypomania episodes in patients with bipolar disorder; avoid monotherapy in bipolar disorder; screen patients presenting with depressive symptoms for bipolar disorder Use caution in hepatic or renal impairment Neonates exposed to serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs) late in 3rd trimester of pregnancy have developed complications necessitating prolonged hospitalization, respiratory support, and tube feeding Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years) When discontinuing, taper dosage to avoid flulike symptoms May cause increase in nervousness, anxiety, or insomnia May impair ability to operate heavy machinery; depresses CNS Bone fractures reported with antidepressant therapy; consider possibility if patient experiences bone pain May cause snificant increase in serum cholesterol Dose-dependent anorectic effects and weht loss reported in children and adult patients Dose-related increase in systolic and diastolic pressure reported Eosinophilic pneumonia and interstitial lung disease reported SAIDH and hyponatremia reported SSRIs Potentially life-threatening serotonin syndrome with SSRIs and SNRIs when used in combination with other serotonergic agents including TCAs, buspirone tryptophan, fentanyl, tramadol, lithium, and triptans; symptoms include tremor, myoclonus, diaphoresis, nausea, vomiting, flushing, dizziness, hyperthermia with features resembling neuroleptic malnant syndrome, seizures, ridity, autonomic instability with possible rapid fluctuations of vital sns, and mental status changes that include extreme agitation progressing to delirium and coma Venlafaxine in patient being treated with linezolid or IV methylene blue increases risk of serotonin syndrome; if linezolid or IV methylene blue must be administered, discontinue venlafaxine immediately and monitor for central nervous system (CNS) toxicity; therapy may be resumed 24 hours after last linezolid or methylene blue dose or after 2 weeks of monitoring, whichever comes first SSRIs and SNRIs may impair platelet aggregation and increase the risk of bleeding events, ranging from ecchymoses, hematomas, epistaxis, petechiae, and GI hemorrhage to life-threatening hemorrhage; concomitant use of aspirin, NSAIDs, warfarin, other anticoagulants, or other drugs known to affect platelet function may add to this risk Control hypertension before initiating treatment; monitor blood pressure regularly during treatment Risks of sustained hypertension, hyponatremia, and impeded heht and weht in children Drug-laboratory test interactions: False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been observed during venlafaxine therapy because of lack of specificity of the screening tests May cause or exacerbate sexual dysfunction "Bicyclic" antidepressant; drug is structurally unrelated to SSRIs, MAOIs, and tricyclic antidepressants (TCAs), but it and its metabolite are potent inhibitors of serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake; it does not have MAOI activity or activity for H1 histaminergic, muscarinic cholinergic, or alpha2-adrenergic receptors The above information is provided for general informational and educational purposes only.
Is higher dose of effexor better
Is higher dose of effexor better
Based on a total of 46 ratings/reviews, Effexor XR has an overall score of 6.46. Effexor boosts serotonin levels in the synapse in similar fashion to other SSRI's. Missing a dose is catastrophic (nhtmares and extreme grogginess/drowsiness).
Venlafaxine, formerly sold as Effexor, is a prescription drug used to treat depression, anxiety, social phobia, and panic disorder. CIALIS MAIN INFORMATION
Is higher dose of effexor better:
Rating: 98 / 100
Overall: 97 Rates