Efficacy of Propranolol in Neuroleptic-Induced Akathesia. Journal. HOME BAUM HEDLUND CONTACT US Suicide Extreme Agitation Hostility & Aggression Withdrawal Reactions Other Side Effects Birth Defects Autism Lack of Efficacy Chemical Imbalance Myth Pharmaceutical Fraud Articles Resources Helpful Links FDA Alerts FDA Med Watch SSRI - INDUCED EXTRAPYRAMIDAL SIDE-EFFECTS AND AKATHISIA Implications for Treatment By R. Lane “This paper will first review the potential of SSRIs, drugs which apparently enhance serotonin neurotransmission, to induce EPS and akathisia: second, give some guidelines for the prevention, early recognition and management of these effects; and third explore the pharmacodynamic mechanisms underlying these effects and possible differences in potential to induce these effects amongst the SSRIs.” “One of the most serious EPS reported with the SSRIs is akathisia. Akathisia may occur during treatment with antidepressants ... The effects of propranolol, 20 to 30 mg/day, on neuroleptic-induced akathesia were compared with those of lorazepam, 2 mg/day, and periods of no treatment.
Propranolol in the treatment of neuroleptic-induced SSRI-induced akathisia is a relatively rare event but is frequently unrecognized when it does occur.” “In addition to the obvious motor(objective) manifestations of ‘inability to sit still’, most researchers agree that akathisia has a strong psychological (subjective) component. The most outstanding feature of akathisia is the subjective distress.” “It has been suggested that SSRI-induced akathisia may be associated with the emergence of ego-dystonic suicidality (Lipinski et al., 1989: Rothschild and Locke, 1991: and Opler, 1992). Efficacy of propranolol in neuroleptic-induced akathesia. Comparison of metoprolol and propranolol in the treatment of akathisia. Noradrenergic mechanisms in akathisia treatment with propranolol and clonidine.
Propranolol-induced tardive dyskinesia in a patient with Akathisia is a feeling of "inner restlessness", a constant urge to be moving. My experience was made much worse because my psychiatrist did not recognize it as akathisia, instead attempting to treat me with benzodiazepines and anti-psychotics. (He still doesn't believe me, but all the symptoms fit, and now that I've demonstrated that propranolol works for me, he has dened to humor me.) How often does this happen? One month later, the patient was again given propranolol40 mg twice daily with prompt disappearance of the Gen Psychiatry 4. Lipinski JF, Zubenko GS, Cohen BM, Barreira PJ Propranolol in the treatment of neuroleptic-induced akathisia.
Akathesia treatment with propranolol:
Rating: 100 / 100
Overall: 98 Rates